آلية تقليل المناعة الامية لفيرس اللقاح Mechanisms of MDAs interference
خمس طريق او أليات
الاولى antigen neutralization
MDAs neutralize and damage the replication of live virus vaccine through blocking attachment and entry of virus into cells
التانية epitope masking
immunodominant epitopes in the virus are recognized and bound by MDAs, blocking the recognition by B cell receptor
الثالثة inhibition by Fcγ receptor IIB (FcγRIIB)-mediated signaling
BCR, antigens, MDAs and Fc receptor (FcγRIIB) combine together to downregulate the signal of B cell stimulation
الرابعة clearance of MDA-coated vaccine antigens
MDAs bind to viral antigen on the cells, which normally would attract phagocytes and natural killer (NK) cells to clear the virusinfected cells
الخامسة shaping the early-life B cells repertoire
MDAs interfere with antigen-specific plasma cells and memory B cells by shaping the earlylife
B cells repertoire within germinal centers